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: Stat3 Regulates Alloreactive T Cell Susceptibility Towards PD-L1-Mediated Tolerance Signaling, Gvhd and GVL Activity

Researchers

Presenter

  • Shijie Yang

Principal Investigators

  • Xiaoqi Wang

  • Yuankun Zhang

  • Deye Zeng

  • Qingxiao Song

  • Paul J Martin

  • Xi Zhang

  • Defu Zeng

Medical Centers

  • Diabetes & Metabolic Research Institute, Beckman Research Institute of City of Hope, Duarte, CA

  • Department of Pathology, Daping Hospital, Army Medical University, Chongqing, China

  • Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, CA.

  • Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China

  • Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China

  • Fred Hutchinson Cancer Resaerch Center, Seattle, WA

Locations

  • United States

  • China

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Autoimmune (AI)

Disease

  • Acute lymphoblastic leukemia

  • Graft-versus-host disease

  • B cell lymphomas

  • Lymphomas

Biomarkers

  • Breakpoint Cluster Region

  • Cluster of Differentiation 4

  • Programmed cell death protein 1

  • Cluster of differentiation 8A

  • Cyclin D1

  • Regulatory T cells

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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