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: Next Generation Sequencing-Based BCR-ABL1 Kinase Domain Mutation Screening in De Novo and Tyrosine Kinase Inhibitor-Resistant Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of a Prospective Study

Researchers

Presenter

  • Simona Soverini

Principal Investigators

  • Margherita Martelli

  • Caterina De Benedittis

  • Cristina Papayannidis

  • Antonio Percesepe

  • Maria Antonella Laginestra

  • Simona Sica

  • Federica Sor

  • Francesco Albano

  • Livio Pagano

  • Marianna Criscuolo

  • Sara Galimberti

  • Marzia Salvucci

  • Mario Annunziata

  • Giovanni Marconi

  • Antonio Curti

  • Sabina Russo

  • Annalisa Imovilli

  • Daniele Mannina

  • Dario Ferrero

  • Manuela Stulle

  • Claudia Basilico

  • Elisabetta Abruzzese

  • Flavio Mignone

  • Stefano A. Pileri

  • Giovanni Martinelli

  • Michele Cavo

Medical Centers

  • Hematology/Oncology L. and A. Sera gnoli, University of Bologna, Bologna, Italy

  • Hematology/Oncology L. and A. Sera gnoli, University of Bologna, Bologna, Italy

  • DIMES - Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology, University of Bologna, Bologna, Italy

  • Department of Medicine and Surgery, Hematology and BMT Unit, University of Parma, Parma, Italy

  • Department of Experimental, Diagnostic, and Specialty Medicine, Hematopathology Section, Bologna, Italy

  • Hematology Department, Fondazione Policlinico Universitario A. Gemelli, Universit Cattolica del Sacro Cuore, Rome, Italy

  • Oncology Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Catholic University of Rome, Rome, Italy

  • Hematology Unit, Dept. of Emergency and Organ Transplantation, University of Bari, Bari, Italy

  • Institute of Infectious Disease, Fondazione Policlinico A. Gemelli- IRCCS- Università Cattolica S. Cuore, Roma, Italy

  • Institute of Infectious Disease, Fondazione Policlinico A. Gemelli- IRCCS- Università Cattolica S. Cuore, Roma, Italy

  • Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

  • Medical Oncology Unit, S.Maria delle Croci Hospital, Ravenna, Italy

  • Hematology, Ospedale Cardarelli, NAPOLI, Italy

  • Dipartimento di Medicina Interna, AOU Policlinico di Messina, Messina, Italy

  • Ematologia, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia,

  • Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy

  • A.O.U. Citta della Salute e della Scienza di Torino, Torino, Italy

  • Hematology Unit,Trieste,Italy

  • ASST dei Sette Laghi, Presidio di Varese Osp Circolo Fondazione Macchi,Varese,Italy

  • Hematology, S.Eugenio Hospital, Rome, Italy

  • Department of Science and Innovation Technology (DISIT), University of Piemonte Orientale, Alessandria, Italy

  • Unit of Hematopathology,European Institute of Oncology,Milano,Italy

Locations

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

Drug/Treatment

  • Blinatumomab

  • Ponatinib

  • dasatinib

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • Prospective

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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