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: The Mutational Profile of Pediatric Therapy-Related Myeloid Neoplasms

Researchers

Presenter

  • Jason R Schwartz

Principal Investigators

  • Michael P Walsh

  • Jing Ma

  • Tamara Lamprecht

  • Raul C Ribeiro

  • Jeffery M. Klco

Medical Centers

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • St. Jude Children's Research Hospital, Memphis, TN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Musculoskeletal

  • Genetic Disorder

Disease

  • Acute lymphoblastic leukemia

  • Hematological malignancies

  • Alpha-thalassemia myelodysplasia syndrome

  • Acute myelocytic leukemia

  • Myeloid neoplasms

  • Brain cancer

  • Solid malignancies

  • Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis

Biomarkers

  • Mitogen-activated protein kinase

  • Breakpoint Cluster Region

  • ETV6-RUNX1

  • GTPase Nras

  • Hematocrit

  • Histone-lysine N-methyltransferase 2A

  • KRAS proto-oncogene, GTPase

  • MDS1 And EVI1 Complex Locus

  • Tumor protein p53

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

  • Neurofibromatosis type 1

Drug/Treatment

  • TP53

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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