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: Significant In Vivo Sensitivity to Aurora Kinase Inhibition in TCF3-Hlf rearranged Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Bill H. Chang

Principal Investigators

  • Jessica Leonard

  • Joelle Wolf

  • Michelle Degnin

  • Kyle Lenz

  • Beth Wilmot

  • Charles G. Mullighan

  • Mignon L. Loh

  • Stephen P. Hunger

  • Jeffrey W. Tyner

  • Brian J. Druker

Medical Centers

  • OHSU, Portland, OR

  • Department of Neurosurgery, Oregon Health and Science University, Portland, OR

  • Department of Pediatrics, OHSU, Portland, OR

  • Knight Cancer Institute, Portland, OR

  • Oregon Health and Science University, Portland, OR

  • Knight Cancer Institute, Division of Bioinformatics and Computational Biology, Oregon Health and Science University, Portland, OR

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Pediatrics, UCSF Benioff Children's Hospital and the Helen Diller Family, San Francisco, CA

  • Department of Pediatrics, Division of Oncology and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

  • Knight Cancer Institute, Oregon Health and Science University, Portland, OR

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • AMP-activated protein kinase

  • B-cell lymphoma 2

  • Breakpoint Cluster Region

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Polo-like kinase 1

  • Cyclic AMP-dependent protein kinase

  • Isocitrate dehydrogenase 1

  • Serine/threonine-protein kinase mTOR

  • Signal transducer and activator of transcription 3

  • PI3K/AKT

  • Ataxia-telangiectasia mutated

Drug/Treatment

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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