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: A Phase II Study of Pegylated Asparaginase, Cyclophosphamide, Rituximab, and Dasatinib Added to the UCSF 8707 (Linker 4-drug) Regimen with Liposomal Cytarabine CNS Prophylaxis for Adults with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL): University of California Hematologic Malignancies Consortium Study (UCHMC) 1401

Researchers

Presenter

  • Matthew J. Wieduwilt

Principal Investigators

  • Brian A. Jonas

  • Gary J. Schiller

  • Lin Liu

  • Carolyn Mulroney

  • Gabriel N. Mannis

  • Dimitrios Tzachanis

  • Januario E. Castro

  • Edward D Ball

  • Peter T. Curtin

  • Charalambos Andreadis

  • Aaron C. Logan

  • Jesika Reiner

  • Lloyd E. Damon

Medical Centers

  • University of California, San Diego, Moores Cancer Center, La Jolla, CA

  • University of California, Davis Comprehensive Cancer Center, Sacramento, CA

  • David Geffen School of Medcn at UCLA, Los Angeles, CA

  • University of California, San Diego, La Jolla, CA

  • UCSD Moores Cancer Center, La Jolla, CA

  • Department of Medicine, Division of Hematology and Blood and Marrow Transplantation, University of California, San Francisco, San Francisco, CA

  • University of California, San Diego, La Jolla, CA

  • Mayo Clinic, Scottsdale, AZ

  • Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA

  • UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA

  • Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA

  • Division of Gynecologic Oncology, University of California, San Francisco, San Francisco, CA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Hematological malignancies

  • Lymphomas

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • B-lymphocyte antigen CD20

  • Hematocrit

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • 6-mercaptopurine

  • Allmercap

  • Daunorubicin

  • Methotrexate

  • Asparaginase

  • Vincristine

  • Cytarabine liposomal

  • leucovorin

  • Prednisone

  • Etoposide

  • Etoposide phosphate

  • Rituximab

  • dasatinib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • II

Study Id's

  • NCT02043587

Sponsors

  • N/A

Result

  • N/A

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