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: Statins Potentiate Aminopeptidase Inhibitor (pro)Drug Activity in Acute Myeloid Leukemia Cells

Researchers

Presenter

  • Jacqueline Cloos

Principal Investigators

  • Godefridus J Peters

  • Marjon Al

  • Yehuda G Assaraf

  • Lixia Wang

  • Jack W. Singer

  • Jorge E. Cortes

  • Gert J. Ossenkoppele

  • Gerrit Jansen

Medical Centers

  • Cancer Center Amsterdam, Department of Neurosurgery, VU University Medical Center, Amsterdam, Netherlands

  • Cancer Center Amsterdam, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands

  • Amsterdam Rheumatology and immunology Center, Department of Rheumatology and Clinical Immunology, Amsterdam UMC /University of Amsterdam, Amsterdam, Netherlands

  • Faculty of Biology, The Fred Wyszkowski Cancer Research, The Technion-Israel Institute of Technology Laboratory, Haifa, Israel

  • CTI BioPharma Corporation, Seattle, WA

  • CTI BioPharma, Seattle, WA.

  • Department of Bioinformatics, The University of Texas MD Anderson Cancer Center, Houston, TX

  • Department of Hematology, Amsterdam UMC, Vrije Universiteit Cancer Center, Amsterdam, Netherlands

Locations

  • Netherlands

  • Israel

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Non Small Cell Lung cancer

  • Nasopharyngeal carcinoma

  • Acute myelocytic leukemia

  • Small cell lung cancer

  • Breast cancer

  • Lung Cancer

  • Solid malignancies

Biomarkers

  • Serine/threonine-protein kinase mTOR

Drug/Treatment

  • Daunorubicin

  • Fluvastatin

  • Simvastatin

  • Pravastatin sodium

  • CHR-2797

  • Lavastatin

  • Ubenimex

  • FTI-277

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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