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: Acadesine Elicits a Rapid Epigenetic Reprograming of Immediate Early Genes through the Protein Kinase D1 Pathway in Acute Lymphoblastic Leukemia Cells Undergoing Energy/Metabolic Stress

Researchers

Presenter

  • Guangyan C Sun

Principal Investigators

  • Anna C Shvab

  • Bin C Li

  • Felipe C Beckedorff

  • Guy Jacques Leclerc

  • Ramin Shiekhattar

  • Julio C Barredo

Medical Centers

  • Pediatrics, University of Miami Leonard M Miller School of Med, Miami, FL

  • University of Miami Miller School of Medicine, Miami, FL

  • University of Miami Miller School of Medicine, Miami, FL

  • University of Miami/Sylvester Cancer Center, Miami, FL

  • Biochemistry, University of Miami, Miami, FL

  • Gastroenterology, University of Miami Leonard M. Miller School of Medicine, Miami, FL

  • Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Genetic Disorder

Disease

  • Acute lymphoblastic leukemia

  • Solid malignancies

  • AICAR transformylase/IMP cyclohydrolase deficiency

Biomarkers

  • AMP-activated protein kinase

  • NF-kappa-B inhibitor alpha

  • Breakpoint Cluster Region

  • Nucleoside diphosphate kinase A

  • Pyruvate dehydrogenase kinase 1

  • Histone deacetylase 4

  • JunB proto-oncogene, AP-1 transcription factor subunit

Drug/Treatment

  • Adenosine

  • Adenosine Intravenous

  • Acadesine

  • AICAR

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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