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: Activin A, a Potential Key Factor of the Malignant Bone Marrow Niche, Enhances B-Cell Precursor-Acute Lymphoblastic Leukemic Cell Migratory and Invasive Properties

Researchers

Presenter

  • Erica Dander

Principal Investigators

  • Federica Portale

  • Daniela Silvestri

  • Giulia Cricr

  • Silvia Bresolin

  • Stefania Gaspari

  • Barbara Russo

  • Monica Lupi

  • Paolo Ubezio

  • Geertruy te Kronnie

  • Maria Grazia Valsecchi

  • Franco Locatelli

  • Carmelo Rizzari

  • Andrea Biondi

  • Giovanna D'Amico

Medical Centers

  • Centro Ricerca Tettamanti, Pediatric Dep, University of Milan-Bicocca, Fondazione MBBM, Monza, Italy

  • Universita' Degli Studi Di Milano-Bicocca, Center of Biostatistics for Clinical Epidemiology, School of Medicine and Surgery, Monza, Italy

  • Pediatric Dep, University of Milan-Bicocca, Fondazione MBBM, Monza, Italy

  • University of Padova, Department of Mother and Child Health, Padova, Italy

  • IRCCS Bambino Gesù Children's Hospital, Department of Hematology and Oncology, Rome, Italy

  • Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy

  • Department of Pediatric Hematology and Oncology, Cell and Gene Therapy,IRCCS Bambino Gesù Children's Hospital,Roma,Italy

Locations

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Solid malignancies

Biomarkers

  • Activin A

  • Interleukin 1 beta

  • Interleukin 6

  • Mesenchymal stem cells

  • Transforming growth factor beta

Drug/Treatment

  • SB431542

  • CXCL12

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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