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: Regulatory Genetic Variation at the S100B Gene Associates with Vaso-Occlusive Manifestations in Sickle Cell Disease

Researchers

Presenter

  • Xu Zhang

Principal Investigators

  • Wei Zhang

  • Santosh L. Saraf

  • Sergei Nekhai

  • Mark T Gladwin

  • Roberto Machado

  • Victor R. Gordeuk

Medical Centers

  • Department of Psychology, University of Illinois at Chicago, Chicago, IL

  • Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL

  • Center for Sickle Cell Disease, Howard University, Washington, DC

  • Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA

  • Department of Medical Oncology, Indiana University, Indianapolis, IN

  • University of Illinois at Chicago, College of Medicine, Rockford, IL.

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

  • Cardiovascular (CVS)

  • Genetic Disorder

  • Blood/haematological Diseases

  • Pulmonary/Respiratory Diseases

  • Musculoskeletal

Disease

  • Venous thrombosis

  • Acute chest syndrome

  • Sickle cell anemia

  • Avascular necrosis

  • Ischemic stroke

  • Thalassemia

  • Anemia

  • Stroke

Biomarkers

  • Peripheral blood mononuclear cell

  • Lactate dehydrogenase

  • S100 calcium-binding protein B

  • Stearoyl-CoA desaturase

Drug/Treatment

  • Hydroxyurea

  • Hydroxycarbamide

  • Stribild

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • III

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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