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699 : DYRK1A Is Required to Alleviate Replication Stress in KMT2A-Rearranged Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Christian Hurtz

Principal Investigators

  • Gerald Wertheim

  • Rahul S. Bhansali

  • Sung June Lee

  • Anil Kumar

  • Anne Lehman

  • Joseph Patrick Loftus

  • Grace Jeschke

  • John D. Crispino

  • Thierry Besson

  • Junwei Shi

  • Srividya Swaminathan

  • Sarah K Tasian

  • Martin P. Carroll

Medical Centers

  • University of Pennsylvania, Philadelphia, PA

  • Department of Pathology, The Children's Hospital of Philadelphia, Philadelphia, PA

  • Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

  • Division of Hematology/Oncology, Northwestern University, Chicago, IL

  • Systems Biology, City of Hope, Monrovia, CA

  • Department of Systems Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA

  • University of Pennsylvania, Philadelphia, PA

  • Center for Childhood Cancer Research, Childrens Hospital of Philadelphia, Philadelphia, PA

  • Division of Hematology/Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

  • Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN

  • Normandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000, Rouen, France

  • Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

  • Department of Hematologic Malilgnancies Translational Science, Beckman Research Institute, City of Hope, Duarte, CA

  • Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

  • University of Pennsylvania, Philadelphia, PA

Locations

  • United States

  • France

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

Disease

  • Acute lymphoblastic leukemia

  • Down syndrome

Biomarkers

  • Breakpoint Cluster Region

  • Cyclin D3

Drug/Treatment

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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