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695 : Combined Inhibition of CXCR4 Signaling and System xc- Transporter Activity Induces Synthetic Lethality in T-ALL Cells By Suppressing Gsh and Inducing Ferroptosis

Researchers

Presenter

  • Jun Xia

Principal Investigators

  • Stephanie Sun

  • Matthew RM Jotte

  • Geoffrey L Uy

  • Ella Sorani

  • Abi Vainstein

  • Liron Shemesh Davish

  • Katherine E Caldwell

  • William G Hawkins

  • Daniel C. Link

Medical Centers

  • Division of Oncology, Department of Medicine, Washington University School of Medicine, O Fallon, MO

  • Washing University, St.Louis

  • The University of Chicago Medical Center, Chicago, IL

  • Washington University School of Medicine, St. Louis, MO

  • BioLineRx, Modiin, Israel

  • BioLineRx LTD, Jerusalem, Israel

  • BiolineRx. Ltd, Modi'in, Israel

  • Washington University School of Medicine, St. Louis, MO

  • Washington University School of Medicine, St. Louis, MO

  • Washington University School of Medicine, St. Louis, MO

Locations

  • United States

  • Israel

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Hematological malignancies

  • Solid malignancies

  • T-cell acute lymphoblastic leukemia

Biomarkers

  • Proto-oncogene tyrosine-protein kinase ROS

  • C-X-C motif chemokine receptor 4

  • Glutathione

Drug/Treatment

  • glutathione

  • Nelarabine

  • BL-8040

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • NCT02763384

Sponsors

  • N/A

Result

  • N/A

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