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319 : Extracellular Protein Disulfide Isomerase Cleaves Allosteric Disulfides in Histidine-Rich Glycoprotein to Regulate Thrombus Formation

Researchers

Presenter

  • Shuai Chen

Principal Investigators

  • Xu-Lin Xu

  • Joyce Chiu

  • Sheryl Bowley

  • Yi Wu

  • Philip J. Hogg

  • Chao Fang

Medical Centers

  • Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

  • The Centenary Institute, National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia

  • Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA

  • Cyrus Tang Hematology Center, Soochow University, Suzhou, China

  • Department of Pharmacology, School of Basic Medicine, Tongji Medical College, HUST, Wuhan, China

Locations

  • China

  • Australia

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Obstetrics/Gynecology

Disease

  • Venous thrombosis

  • Twin-reversed arterial perfusion

Biomarkers

  • Nucleoside diphosphate kinase A

Drug/Treatment

  • Cysteine Hydrochloride

  • Heparin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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