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2335 : CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo

Researchers

Presenter

  • Ari Itoh-Nakadai

Principal Investigators

  • Yoriko Saito

  • Mariko Murasawa-Tomizawa

  • Hiroshi Kajita

  • Takehisa Matsumoto

  • Masashi Matsuda

  • Takashi Watanabe

  • Mikako Shirouzu

  • Osamu Ohara

  • Haruhiko Koseki

  • Leonard Shultz

  • Fumihiko Ishikawa

Medical Centers

  • Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

  • RIKEN Systems and Structural Biology Center, Yokohama, Japan

  • Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

  • Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

  • Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan

  • The Jackson Laboratory, Bar Harbor, ME

Locations

  • Japan

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

Disease

  • Diffuse large B-cell lymphoma

  • Acute lymphoblastic leukemia

  • Cytokine release syndrome

  • Hematological malignancies

  • Acute myelocytic leukemia

  • Hodgkin's Lymphoma

  • B cell lymphomas

  • Lymphomas

  • Graft-versus-host disease

Biomarkers

  • Breakpoint Cluster Region

  • Cluster of Differentiation 19

  • Cluster of Differentiation 2AP

  • Cluster of Differentiation 34

  • Cluster of Differentiation 38

  • Cluster of Differentiation 4

  • Cluster of differentiation 45

  • Cluster of Differentiation 56

  • Interleukin-2

  • T-cell receptor

Drug/Treatment

  • Methadone hydrochloride

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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