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2009 : Additional Evidence of Mismatch Repair Pathway As Relapse-Specific Alteration in B-Cell Precursor Acute Lymphoblastic Leukemia: Discovery of Novel Somatic Mutation in MLH1 and Establishment of New Cell Line with MLH1 Mutation

Researchers

Presenter

  • Keisuke Kato

Principal Investigators

  • Ai Yoshimi

  • Norihito Ikenobe

  • Chie Kobayashi

  • Kazutoshi Koike

  • Masahiro Tsuchida

Medical Centers

  • Ibaraki Childrens Hospital, Mito, Japan

  • Institute of Clinical Medicine, Univ. of Tsukuba, Tsukuba, Ibaraki, Japan

Locations

  • Japan

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Mismatch repair endonuclease PMS2

  • MutL Homolog 1

  • MutS Homolog 6

  • MutS protein homolog 2

  • Paired box 5

  • Protein Tyrosine Phosphatase, Non-Receptor Type 11

  • CREB-binding protein

  • Fms related tyrosine kinase 3

  • GTPase Nras

  • KRAS proto-oncogene, GTPase

  • Tumor protein p53

Drug/Treatment

  • TP53

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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