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1938 : Treatment-Free Intervals Mitigate T-Cell Exhaustion Induced By Continuous CD19xCD3-BiTE® Construct Stimulation in Vitro

Researchers

Presenter

  • Nora Zieger

Principal Investigators

  • Alyssa Nicholls

  • Jan Wulf

  • Gerulf Hnel

  • Maryam Kazerani Pasikhani

  • Veit Buecklein

  • Bettina Brauchle

  • Anetta Marcinek

  • Daniel Nixdorf

  • Lisa Rohrbacher

  • Michaela Scheurer

  • Roman Kischel

  • Karsten Spiekermann

  • Oliver Weigert

  • Sebastian Theurich

  • Michael von Bergwelt

  • Marion Subklewe

Medical Centers

  • Laboratory for Translational Cancer Immunology, Gene Center of the LMU Munich, Germany

  • Department of Medicine III, University Hospital Grosshadern/LMU, Munich, Germany

  • Amgen Research GmbH, Munich, Germany

  • Experimental Leukemia and Lymphoma Research (ELLF), University Hospital, LMU Munich, Munich, Germany

  • German Cancer Consortium, CCU Neurooncology, German Cancer Research Center, Heidelberg, Germany

Locations

  • Germany

Companies

  • AMGEN Research (Muni

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Cluster of Differentiation 19

  • Cluster of Differentiation 2

  • Cluster of Differentiation 2AP

  • Cluster of differentiation 8A

  • Cytokine

  • Interleukin-2

  • Tissue factor pathway inhibitor

  • T-cell function

Drug/Treatment

  • Blinatumomab

  • IFN-lambda

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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