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268 : Superior Event-Free Survival with Blinatumomab Versus Chemotherapy in Children with High-Risk First Relapse of B-Cell Precursor Acute Lymphoblastic Leukemia: A Randomized, Controlled Phase 3 Trial

Researchers

Presenter

  • Franco Locatelli

Principal Investigators

  • Carmelo Rizzari

  • Joan Morris

  • Bernd Gruhn

  • Thomas Klingebiel

  • Rosanna Parasole

  • Christin Linderkamp

  • Christian Flotho

  • Arnaud Petit

  • Concetta Micalizzi

  • Noemi Mergen

  • Abeera Mohammad

  • Cornelia Eckert

  • Anja Moericke

  • Mary Sartor

  • Ondrej Hrusak

  • Christina Peters

  • Vaskar Saha

  • Arend von Stackelberg

Medical Centers

  • Department of Pediatric Hematology and Oncology , IRCCS Ospedale Bambino Gesu, Rome , Italy

  • Amgen Research (Munich), Munich, Germany

  • S. Gerardo Hospital, University of Milano Bicocca, Monza, Italy

  • Amgen Inc, Thousand Oaks, CA

  • Department of Pediatrics, Department of Pediatrics, Jena, Germany

  • Department for Children and Adolescents, University Hospital Frankfurt, Frankfurt, Germany

  • Dept Pediatric Hemato-Oncology, Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon, Napoli, Italy, NAPOLI, Italy

  • Medizinische Hochschule Hannover, Hannover, Germany

  • Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

  • Hopital Trousseau, PARIS, France

  • Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini, Genova, Italy

  • Amgen Research (Munich), Munich, Germany

  • Global Biostatistical Science, Amgen Ltd, Uxbridge, United Kingdom

  • Department of Pediatric Oncology/Hematology, Campus Rudolf Virchow, Charite University Hospital, Berlin, Germany

  • Department of Paediatrics, University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, Germany, Kiel, Germany

  • Westmead Institute for Medical Research, Sydney, Australia

  • CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Charles University CLIP, Prague, Czech Republic

  • St. Anna Children s Hospital, Vienna, Austria

  • Tata Translational Cancer Research Centre, Tata Medical Center, Kolkata, India

  • Department of Pediatric Oncology/Hematology, Charite Medical University Berlin, Berlin, Germany.

Locations

  • Italy

  • Germany

  • United States

  • France

  • United Kingdom

  • Australia

  • Czech Republic

  • Austria

  • India

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • N/A

Drug/Treatment

  • PEG-asparaginase

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • Blinatumomab

  • Daunorubicin

  • Methotrexate

  • Asparaginase

  • Prednisolone

  • Vincristine

  • Cytarabine liposomal

  • Ifosfamide

Outcome

  • N/A

Study Design

  • Randomized

  • Controlled

Phase

  • III

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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