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1093 : Incidence and Therapeutic Implications of Germline TP53 Mutations in Hypodiploid Childhood Acute Lymphoblastic Leukemia: A Retrospective Analysis of the Italian Cohort

Researchers

Presenter

  • Laura Rachele Bettini

Principal Investigators

  • Claudia Saitta

  • Barbara Buldini

  • Geertruij Te Kronnie

  • Stefano Rebellato

  • Daniela Silvestri

  • Elena Barisone

  • Andrea Pession

  • Marco Rabusin

  • Concetta Micalizzi

  • Franco Locatelli

  • Carmelo Rizzari

  • Maria Grazia Valsecchi

  • Andrea Biondi

  • Grazia Fazio

  • Giovanni Cazzaniga

Medical Centers

  • Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy

  • Woman and Child Health Department, OncoHematology Lab, Università degli Studi di Padova, Padova, Italy

  • Centro Operativo di Ricerca Statistica, Fondazione Tettamanti, School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy

  • Regina Margherita Children Hospital, torino, Italy

  • Sant'Orsola-Malpighi Hospital, "Lalla Seràgnoli" Institute, Bologna, Italy

  • Institute of Maternal and Child Health, Trieste, Italy

  • Hematology Unit, Istituto Giannina Gaslini, Genoa, Italy

  • Dept of Pediatric Hematology/Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children’s Hospital, Sapienza, University of Rome, Italy, Rome, Italy

  • Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy

  • Bicocca Bioinformatics, Biostatistics and Bioimaging Centre, Department of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy

  • Genetics, Univ. Milan Bicocca, Monza, Italy

Locations

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Tumor protein p53

  • DNA index

Drug/Treatment

  • TP53

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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