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976 : HESTER: A Phase II Study Evaluating Efficacy and Safety of Tisagenlecleucel Reinfusion in Pediatric and Young Adult Patients with Acute Lymphoblastic Leukemia Experiencing Loss of B-Cell Aplasia

Researchers

Presenter

  • Michael W Boyer

Principal Investigators

  • Sonali Chaudhury

  • Kara L Davis

  • Timothy Alan Driscoll

  • Stephan A Grupp

  • Michelle Hermiston

  • Samuel John

  • Amy K Keating

  • Christina Kovacs

  • Andrea Magley

  • Gary Douglas Myers

  • Christine L Phillips

  • Michael A Pulsipher

  • Das Purkayastha

  • Julie-An Talano

  • Jennifer Willert

Medical Centers

  • University of Utah School of Medicine, Salt Lake City, UT

  • Northwestern University, Feinberg School of Medicine, Chicago, IL

  • Division of Hematology, Oncology and Stem Cell Transplant, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA

  • Pediatric Transplant and Cellular Therapy, Duke University Medical Center, Durham, NC

  • Childrens Hospital of Philadelphia, Philadelphia, PA

  • Department of Pediatrics (Pediatric Hematology/Oncology), University of California San Francisco, San Francisco, CA

  • Division of Hematology/Oncology, The University of Texas Southwestern Medical Center, Dallas, TX

  • Children's Hospital Colorado and University of Colorado, Aurora, CO

  • Novartis Pharmaceutical Corporation, East Hanover, NJ

  • Childrens Mercy Hospital, Kansas City, MO

  • Univ. of Cincinnati College of Medicine, Cincinnati, OH.

  • Children’s Hospital Los Angeles Cancer and Blood Disease Institute, Los Angeles, CA

  • The Medical College of Wisconsin, Milwaukee, WI

Locations

  • United States

Companies

  • Novartis AG

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • Cluster of Differentiation 19

Drug/Treatment

  • tisagenlecleucel-t

Outcome

  • N/A

Study Design

  • Open Label

  • Multicenteric

Phase

  • II

Study Id's

  • NCT04225676

Sponsors

  • N/A

Result

  • N/A

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