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PD4-04 : Leronlimab, a humanized monoclonal antibody to CCR5, restrains breast cancer metastasis and enhances cell death induced by DNA damaging chemotherapies

Researchers

Presenter

  • Richard G Pestell

Principal Investigators

  • Massimo Cristofanilli

  • Hallgeir Rui

  • Xuanmao Jiao

  • Min Wang

Medical Centers

  • Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, Pennsylvania Biotechnology Center,, Wynnewood, PA

  • Northwestern University, Chicago, IL

  • Department of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Urology

Disease

  • Pancreatic cancer

  • Prostate cancer

  • Breast cancer

  • Colorectal Cancer

  • Melanoma

  • Solid malignancies

  • Triple-negative breast cancer

Biomarkers

  • C-C Motif Chemokine Ligand 11

  • C-C Motif Chemokine Ligand 13

  • C-C Motif Chemokine Ligand 3

  • C-C Motif Chemokine Ligand 4

  • C-C Motif Chemokine Ligand 5

  • C-C Motif Chemokine Receptor 5

  • Circulating tumor cells

  • C-X-C Motif Chemokine Ligand 13

Drug/Treatment

  • Pembrolizumab

  • Carboplatin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • III

Study Id's

  • NCT03274804

  • NCT03838367

Sponsors

  • N/A

Result

  • N/A

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