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: A GENOME-WIDE APPROACH IDENTIFIES VARIATION IN THE UGT1A GENE LOCUS AS SIGNIFICANT CONTRIBUTOR TO CHEMOTHERAPY-RELATED HYPERBILIRUBINEMIA

Researchers

Presenter

  • Stefanie V. Junk

Principal Investigators

  • Martin Zimmermann

  • Anja Mricke

  • Julia Alten

  • Rita Beier

  • Birthe Fedders

  • Peter Schtte

  • Laura Hinze

  • Norman Klein

  • Jayaram Vijayakrishnan

  • Eva Ellinghaus

  • Michael Forster

  • Andre Franke

  • Gunnar Cario

  • Christian P. Kratz

  • Martin Schrappe

  • Matthias Schwab

  • Richard S. Houlston

  • Martin Stanulla

Medical Centers

  • Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany

  • Margarete Fischer-Bosch-Institut for Clinical Pharmacology, Stuttgart, Germany.

  • Department of General Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany

  • Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom

  • Clinical Molecular Biology, University Kiel, Kiel, Germany

Locations

  • Germany

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Gastroenterology (GU)

  • Oncology (ONC)

Disease

  • Hyperbilirubinemia

  • Solid malignancies

Biomarkers

  • Breakpoint Cluster Region

  • Circulating tumor cells

  • UDP glucuronosyltransferase family 1 member A1

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • Multicenteric

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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