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: FRACTIONATED DOSING OF ARI-0001 CELLS (A3B1:CD8:4-1BB:CD3Z CAR19) AND EARLY TOCILIZUMAB ADMINISTRATION MAY REDUCE THE INCIDENCE OF SEVERE CYTOKINE RELEASE SYNDROME IN PATIENTS WITH CD19+ MALIGNANCIES

Researchers

Presenter

  • Valentn Ortiz-Maldonado

Principal Investigators

  • Miguel Caballero-Baos

  • Maria Castella

  • Ana Boronat

  • Enric Garcia-Rey

  • Tycho Baumann

  • Marina Daz-Bey

  • Montserrat Torrebadell

  • Albert Catal

  • Federico Ramos

  • Sandra Pont

  • Joan Cid

  • Miquel Lozano

  • Cristina Llanos

  • Berta Marzal

  • David Fernando Moreno

  • Pedro Castro

  • Sara Fernndez

  • Yolanda Jordan

  • Jordi Esteve

  • Josep Maria Canals

  • Esteve Trias

  • Jordi Yage

  • Montserrat Rovira

  • Alvaro Urbano-Ispizua

  • Manel Juan

  • Susana Rives

  • Julio Delgado

Medical Centers

  • Hospital Clinic Barcelona, Barcelona, Spain

  • Pneumology, Hospital de Sant Pau, Barcelona, Spain

  • Immunology Platform Clínic-Sant Joan de Déu,Hospital Clínic Barcelona,Barcelona,Spain

  • Immunology Service, Hospital Clinic Barcelona, Barcelona, Spain

  • Apheresis Unit,Hospital Sant Joan de Déu,Barcelona,Spain

  • Neurology,Hospital Sant Joan de Déu,Barcelona,Spain

  • Apheresis Unit,Hospital Clínic Barcelona,Barcelona,Spain

  • Clinical Trials,Hospital Sant Joan de Deu,Barcelona,Spain

  • Intern Medicine, Hospital Clínic de Barcelona, Barcelona, Spain,

  • Internal Medicine,Hospital Sant Joan de Déu,Barcelona,Spain

  • Universitat de Barcelona, Barcelona, Spain

  • Banc de Sang i Teixits de Barcelona,

Locations

  • Spain

Companies

  • N/A

Study Components

Therapeutic Area

  • Blood/haematological Diseases

  • Oncology (ONC)

  • Autoimmune (AI)

Disease

  • Acute lymphoblastic leukemia

  • Chronic Lymphocytic Leukemia

  • Cytokine release syndrome

Biomarkers

  • Breakpoint Cluster Region

  • Cluster of Differentiation 19

  • Cluster of differentiation 8A

  • Twist-related protein 1

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • Tocilizumab

  • fludarabine tablet

Outcome

  • N/A

Study Design

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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