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: COMBINATION BCL-2 INHIBITOR THERAPY WITH VENETOCLAX AND NAVITOCLAX IN PATIENTS WITH RELAPSED/REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA AND LYMPHOBLASTIC LYMPHOMA

Researchers

Presenter

  • Vinod A. Pullarkat

Principal Investigators

  • Norman J. Lacayo

  • Elias Jabbour

  • Ashish Bajel

  • Jeffrey Rubnitz

  • Jessica Leonard

  • Charles G. Mullighan

  • Seong Lin Khaw

  • Susan I. Vear

  • Ahmed Salem

  • Michelle Schmidt

  • Bo Tong

  • Ying Zhou

  • Jeremy A. Ross

  • Lindsey Bensman

  • Amanda Jacobson

  • Thomas Alexander

  • Robin Norris

Medical Centers

  • Department of Hematology and Hematopietic Cell Transplantation, City of Hope, Duarte, CA

  • University of Chicago, Chicago, IL, United States

  • Pediatric Hematology and Oncology,Stanford University,Palo Alto,United States

  • Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

  • Royal Melbourne Hospital, Parkville, Australia

  • Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, United States

  • School of Nursing, Oregon Health & Science University, Portland, OR

  • Royal Children’s Hospital,Victoria,Australia

  • Pediatrics - Hematology and Oncology,Nationwide Children’s Hospital,Columbus,United States

  • AbbVie Inc., North Chicago, Illinois, United States

  • Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States

  • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Locations

  • United States

  • Australia

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Lymphomas

Biomarkers

  • Breakpoint Cluster Region

Drug/Treatment

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • Asparaginase

  • Vincristine

  • Navitoclax

  • Venetoclax

Outcome

  • N/A

Study Design

  • Open Label

  • Multicenteric

  • Dose Escalation

Phase

  • I

Study Id's

  • NCT03181126

Sponsors

  • N/A

Result

  • N/A

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