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: SAFE TARGETING OF T‐CELL ACUTE LYMPHOBLASTIC LEUKEMIA BY SUBUNIT SELECTIVE GAMMA‐SECRETASE INHIBITION

Researchers

Presenter

  • Charles de Bock

Principal Investigators

  • Roger Habets

  • Lutgarde Serneels

  • Inge Lodewijckx

  • Delphine Verbeke

  • David Nittner

  • Rajeshwar Narlawar

  • Sofie Demeyer

  • James Dooley

  • Adrian Liston

  • Tom Taghon

  • Bart de Strooper

  • Jan Cools

Medical Centers

  • Children's Cancer Institute,University of New South Wales,Randwick,Australia;Center for Human Genetics,KU Leuven,Leuven,Belgium;VIB Center for Cancer Biology,VIB/KU Leuven,Leuven,Belgium

  • VIB Center for Brain and Disease Research,VIB/KU Leuven,Leuven,Belgium;Department of Neurosciences,Leuven Institute for Neuroscience and Disease,Leuven,Belgium

  • Center for Human Genetics, LKI,KU Leuven,Leuven,Belgium;Center for Cancer Biology,VIB,Leuven,Belgium

  • Histopathology Expertise Center,VIB-KU Leuven Center for Cancer Biology,Leuven,Belgium;Department of Oncology,KU Leuven,Leuven,Belgium

  • Department of Neurosciences,Leuven Institute for Neuroscience and Disease, KU Leuven,Leuven,Belgium

  • VIB Center for Brain and Disease Research,VIB/KU Leuven,Leuven,Belgium;Department of Microbiology and Immunology,KU Leuven,Leuven,Belgium

  • Department of Clinical Chemistry, Microbiology and Immunology,Ghent University,Ghent,Belgium;Cancer Research Institute Ghent,Ghent University,Ghent,Belgium

  • VIB Center for Brain and Disease Research,VIB/KU Leuven,Leuven,Belgium;Department of Neurosciences,Leuven Institute for Neuroscience and Disease,KU Leuven,Belgium;Dementia Research Institute,,University College London,London,United Kingdom

Locations

  • Belgium

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • T-cell acute lymphoblastic leukemia

Biomarkers

  • Neurogenic locus notch homolog protein 1

  • Cluster of differentiation 45

Drug/Treatment

  • MRK560

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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