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11282 : Evidence That Links Cyclo-oxygenase-2 Inhibition With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-inflammatory Drugs

Researchers

Presenter

  • Nicholas S Kirkby

Principal Investigators

  • Malak Al-yamani

  • Tim D Warner

  • James Leiper

  • Jane A. Mitchell

Medical Centers

  • MRC Clinical Sciences Ctr, London, United Kingdom

  • William Harvey Research Institute, London, United Kingdom

  • NCRI and Imperial College London, London, United Kingdom

Locations

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Cardiovascular (CVS)

  • Blood/haematological Diseases

  • Pulmonary/Respiratory Diseases

Disease

  • Renal insufficiency

  • Coronary Artery Disease

  • Venous thrombosis

Biomarkers

  • Asymmetric Dimethylarginine

  • Cyclooxygenase-1

  • Cyclooxygenase-2

  • Endothelial cell nitric oxide synthase

Drug/Treatment

  • Prostacyclin

  • Celecoxib

  • ALT-210

  • Rofecoxib

  • Arginine hydrochloride

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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