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138 : Is Less Chemotherapy Detrimental in Adults with Philadelphia Chromosome (Ph)-Positive Acute Lymphoblastic Leukemia (ALL) Treated with High-Dose Imatinib? Results of the Prospective Randomized Graaph-2005 Study

Researchers

Presenter

  • Xavier Thomas

Principal Investigators

  • Sandrine Hayette

  • Celine Berthon

  • Emmanuelle Tavernier

  • Jean-Francois Lambert

  • Marina Lafage

  • Veronique Lheritier

  • Sylvie Chevret

  • Norbert Ifrah

  • Herve Dombret

  • Jean-Michel Cayuela

  • Claire Abbal

  • Francoise Huguet

  • Emmanuel Raffoux

  • Thibaut Leguay

  • Stephane Lepretre

  • Martine Escoffre-Barbe

  • Sebastien Maury

Medical Centers

  • Cytogenetics, CHU Timone, Marseille, France

  • Hematology, Hopital Purpan, Universite Toulouse, Toulouse, France

  • Pediatric Hematology, Institut de Cancerologie de la Loire, Saint Priest En Jarez, France

  • Hematology, CHU Rennes, Rennes, France

  • Hematologie, Centre Henri Becquerel, Rouen, France

  • Department of Radiation Oncology, Centre Hospitalier Lyon Sud, Pierre-Benite, France

  • Hopital Saint-Louis, AP-HP, Universite Paris , Paris, France

  • Hematology, Hopital Henri Mondor, Creteil Cedex, France

  • Molecular Biology and Cytogenetics, Centre Hospitalier Lyon Sud, Pierre Benite, France

  • CHU Bordeaux - Hopital Haut-leveque, Pessac, France,

  • Hematology, CHU, Angers, France

  • University Hospital Geneva, Geneva, Switzerland

  • Molecular Biology, CHUV, Lausanne, Switzerland

  • Hematology, CHRU Lille, Lille, France

  • Hopital Saint-Louis, AP-HP, Universite Paris , Paris, France

  • Neuroradiology, CHUV, Lausanne, Switzerland

  • Hopital Saint-Louis, AP-HP, Universite Paris , Paris, France

  • GRAALL Coordination Center, Centre Hospitalier Lyon Sud, Pierre Benite, France

Locations

  • France

  • Switzerland

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Central Nervous System (CNS)

Disease

  • Acute lymphoblastic leukemia

  • Chronic Myelogenous Leukemia

  • Mental retardation, autosomal dominant 1

  • Mental retardation, autosomal dominant 2

Biomarkers

  • Breakpoint Cluster Region

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • Methotrexate

  • Vincristine

  • Adriamycin injection

  • Nilotinib

  • Imatinib

  • IkT001

Outcome

  • N/A

Study Design

  • non inferiority

  • randomized

Phase

  • NA

Study Id's

  • NCT00327678

Sponsors

  • N/A

Result

  • Interim

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