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137 : Continuous Dose Dasatinib Is Safe and Feasible in Combination with Intensive Chemotherapy in Pediatric Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL): Children's Oncology Group (COG) Trial AALL0622

Researchers

Presenter

  • Kirk R. Schultz

Principal Investigators

  • Lewis B. Silverman

  • Valerie I. Brown

  • Naomi Winick

  • Andrew J. Carroll

  • Nyla A. Heerema

  • Julie M. Gastier-Foster

  • Brent L. Wood

  • Sherri L Mizrahy

  • Thomas E. Merchant

  • Stephen P Hunger

  • Elizabeth Raetz

  • Meenakshi Devidas

  • Michael A. Pulsipher

  • Mignon Loh

  • Bill H Chang

  • William L. Carroll

  • Michael J. Borowitz

Medical Centers

  • Radiation Therapy, St. Jude Childrens Research Hospital

  • Div. Pediatric Hem./Onc./ BMT, BC Childrens Hospital, Vancouver, BC, Canada

Locations

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

Disease

  • Acute lymphoblastic leukemia

  • Chronic Myelogenous Leukemia

  • Pulmonary arterial hypertension

  • Hypophosphatemic rickets

  • Encephalopathy

  • Congestive heart failure

  • Hypertension

  • Peripheral neuropathy

  • Hyperbilirubinemia

  • Epilepsy

Biomarkers

  • Breakpoint Cluster Region

Drug/Treatment

  • Imatinib

  • Methotrexate

  • Ifosfamide

  • Etoposide

  • Etoposide phosphate

  • dasatinib

  • IkT001

  • Gleevec

  • Sprycel

  • 6-mercaptopurine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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