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157 : Biomimetic Synthetic High Density Lipoprotein Nanostructures Target the SR-B1 Receptor and Differentially Manipulate Cellular Cholesterol Flux in Lymphoma Cells: A Novel Treatment Paradigm

Researchers

Presenter

  • Marina G Damiano

Principal Investigators

  • Heng Zhang

  • Sushant Tripathy

  • Andrey Ugolkov

  • Amareshwar T.K. Singh

  • Andrea Luthi

  • Sandeep S. Dave

  • Shad Thaxton

  • Leo I. Gordon

Medical Centers

  • Hematology/Oncology and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA,

Locations

  • United States

Companies

  • Developmental Therap

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

  • Genetic Disorder

Disease

  • Diffuse large B-cell lymphoma

  • Acute lymphoblastic leukemia

  • Acute myelocytic leukemia

  • Burkitt lymphoma

  • B cell lymphomas

  • Lymphomas

  • Hereditary diffuse leukoencephalopathy with spheroids

Biomarkers

  • Breakpoint Cluster Region

  • Cholesterol

Drug/Treatment

  • Aloxistatin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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