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530 : PDE4B Modulates Glucocorticoid Sensitivity in Childhood Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Shuyu E

Principal Investigators

  • Laura B. Ramsey

  • Kristine Crews

  • W. Paul Bowman

  • Michael J. Borowitz

  • William L. Carroll

  • Cheryl L. Willman

  • Sima Jeha

  • Ching-Hon Pui

  • Stephen P. Hunger

  • Mary V. Relling

  • Deepa Bhojwani

  • William E. Evans

  • Huining Kang

  • Yani Ma

  • Jing Chen

  • Jing Yan Tang

  • Nita L. Seibel

  • Heng Xu

  • Jin Cheng

Medical Centers

  • Division of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai, P.R. China, Shanghai, China

  • Cancer Center/Pathology, University of New Mexico, Albuquerque, NM

Locations

  • United States

  • China

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • BCL2 like 11

  • Breakpoint Cluster Region

  • CREB-binding protein

  • Cyclic adenosine monophosphate

Drug/Treatment

  • Glucocorticoid

  • Prednisolone

  • Prednisone

  • forskolin

  • Rolipram

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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