// App-Quantinova.ai

531 : Targeting the Hedgehog Signaling Pathway Limits the Self-Renewal of BCR-ABL1 Positive Leukemia Cells: Molecular Mechanisms

Researchers

Presenter

  • Seiichiro Katagiri

Principal Investigators

  • Seiichi Okabe

  • Yosuke Minami

  • Tomoki Naoe

  • Kazuma Ohyashiki

Medical Centers

  • First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan

  • Department of Pathologic Oncology, Mie University Graduate School of Medicine, Mie, Japan

Locations

  • Japan

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Chronic Myelogenous Leukemia

  • Solid malignancies

Biomarkers

  • Abelson murine leukemia viral oncogene homolog

  • B-cell lymphoma 2

  • Cluster of Differentiation 19

  • Cluster of Differentiation 34

  • Cluster of Differentiation 38

  • Polycomb complex protein

  • Cluster of differentiation 45

  • Histone H2AX

  • Interleukin-2

Drug/Treatment

  • Vismodegib

  • L-Tyrosine

  • Sonidegib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

Copyright © 2026. QuantiNova All rights reserved