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528 : Integrative Analysis of Ikaros-Dependent Changes of Transcriptional Regulation and Tyrosine Phosphorylation Events in Ph+ ALL

Researchers

Presenter

  • Rahul Nahar

Principal Investigators

  • Parham Ramezani-Rad

  • Thomas G. Graeber

  • Brian J. Druker

  • Elisabeth Paietta

  • Ari Melnick

  • Cheryl L. Willman

  • William L. Carroll

  • Markus Muschen

  • Zhengshan Chen

  • Jeffrey W. Tyner

  • Bill H. Chang

  • Bjorn Titz

  • Maike Buchner

  • Christian Hurtz

Medical Centers

  • Portland, OR, USA,

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Philadelphia chromosome–positive (Ph+) ALL

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 9

  • B-cell lymphoma 6

  • Paired box 5

  • Cyclin Dependent Kinase Inhibitor 2A

  • Ras Homolog Family Member Q

  • ETV6-RUNX1

  • Extracellular signal-regulated kinase

  • Spleen tyrosine kinase

  • Tumor protein p53

Drug/Treatment

  • Imatinib

  • IkT001

  • L-Tyrosine

  • TP53

Outcome

  • N/A

Study Design

  • double blind/blinded

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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