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876 : Epigenetic Changes in CEBP? Gene and Xenotransplantation Model of B Cell Precursor Acute Lymphoblastic Leukemia Switching to Monocytoid Lineage During the Early Phase of the Treatment

Researchers

Presenter

  • Julia Starkova

Principal Investigators

  • Tomas Kalina

  • Karel Fiser

  • Maria E. Figueroa

  • Michael Dworzak

  • Jan Zuna

  • Jan Trka

  • Jan Stary

  • Ondrej Hrusak

  • Jean-Pierre Bourquin

  • Ester Mejstrikova

  • Eva Fronkova

  • Marketa Kubricanova Zaliova

  • Leona Reznickova

  • Jana Volejnikova

  • Elena Vodickova

  • Frederik W Van Delft

  • Zuzana Zemanova

  • Gunnar Cario

Medical Centers

  • Department of Oncology and Childrens Research Center, University Childrens Hospital, Zurich, Switzerland

  • Department of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic,

  • Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic

  • Department of Paediatrics, University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, Germany, Kiel, Germany

  • Haemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, United Kingdom

  • Center of Oncocytogenetics, General University Hospital and st Faculty of Medicine, Prague, Czech Republic,

  • Department of Pediatrics, St Anna Childrens Hospital, Medical University of Vienna, Vienna, Austria

Locations

  • Czech Republic

  • Austria

  • Germany

  • Switzerland

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • B-lymphocyte antigen CD20

  • CCAAT enhancer binding protein alpha

  • Cluster of Differentiation 2

  • Cluster of Differentiation 34

  • Cluster of differentiation 45

  • Histone-lysine N-methyltransferase 2A

Drug/Treatment

  • Prednisolone

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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