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879 : Characterizing Rare Variants in Drug Metabolism Genes in Refractory Pediatric High-Risk Pre-B ALL

Researchers

Presenter

  • Joseph Giacalone

Principal Investigators

  • Todd E Druley

Medical Centers

  • Neurology, Pediatrics, Washington Univ in St. Louis, St. Louis, MO

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Hematology-oncology disease

  • Solid malignancies

Biomarkers

  • Mouse double minute 2 homolog

  • Paired box 5

  • Protein Tyrosine Phosphatase, Non-Receptor Type 11

  • Cyclin dependent kinase inhibitor 1A

  • Cytochrome P450 Family 3 Subfamily A Member 4

  • Cytochrome P450 Family 3 Subfamily A Member 5

  • Histone-lysine N-methyltransferase 2A

  • Methylenetetrahydrofolate reductase

  • Thiopurine S-methyltransferase

  • Hormone receptor

  • Ataxia-telangiectasia mutated

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • Glucocorticoid

  • Vincristine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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