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863 : SOX4 enables Oncogenic Survival Signals in Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Huimin Geng

Principal Investigators

  • Lai N Chan

  • Christian Hurtz

  • Hassan Jumaa

  • Ari Melnick

  • Elisabeth Paietta

  • William L. Carroll

  • Cheryl L Willman

  • Veronique Lefebvre

  • Markus Muschen

Medical Centers

  • Children's Hospital Los Angeles/University of Southern California, Los Angeles, CA.

  • Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany,

Locations

  • United States

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Acute myelocytic leukemia

  • Philadelphia chromosome–positive (Ph+) ALL

Biomarkers

  • Mitogen-activated protein kinase 8

  • B-cell lymphoma-extra large

  • Breakpoint Cluster Region

  • p53

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Interleukin-7

  • PI3K/AKT

Drug/Treatment

  • Tamoxifen

  • L-Tyrosine

  • Afimoxifene

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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