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746 : Chemoimmunotherapy with R-CHOP or High Dose Sequential Therapy with Autologous Stem Cell Transplantation (R-HDS) for High Risk Diffuse Large B-Cell Lymphomas Patients: Results of the Randomized R-HDS0305 Trial by Gruppo Italiano Terapie Innovative Nei Linfomi (GITIL)

Researchers

Presenter

  • Corrado Tarella

Principal Investigators

  • Manuela Zanni

  • Valerio Zoli

  • Atto Billio

  • Andrea Gallamini

  • Francesco Di Raimondo

  • Andres J.M. Ferreri

  • Giovanni Pizzolo

  • Giorgio La Nasa

  • Pietro Leoni

  • Alessandro Massimo Gianni

  • Giampietro Semenzato

  • Maurizio Frezzato

  • Leonardo Flenghi

  • Marco Scarano

  • Arianna Masciulli

  • Roberto Marchioli

  • Alessandro Rambaldi

  • Tiziano Barbui

  • Marco Ladetto

  • Anna Maria Barbui

  • Andrea Rossi

  • Paolo Corradini

  • Massimo Di Nicola

  • Caterina Patti

Medical Centers

  • Hematology Unit, Ferrarotto Hospital, Catania, Italy

  • Ospedali Riuniti di Bergamo, Bergamo, Italy

  • Dept. of Hematology, Ospedale V. Cervello, Palermo, Italy

  • Hematology Dept, San Maurizio Regional Hospital, Bolzano, Italy

  • Hematology, University, Padova, Italy

  • Hematology, University, Firenze, Italy

  • Hematology, Az. Osp. S. Croce e Carle, Cuneo, Italy

  • Institute of Hematology, Ospedale Santa Maria della Misericordia, University of Perugia, Perugia, Italy

  • Medical Oncology, Istituto Nazionale dei Tumori, Milano, Italy

  • Division of Hematology, Ospedali Riuniti, Bergamo, Italy

  • Ospedale Mauriziano, Torino, Italy

  • Istituto Mario Negri Sud, Santa Maria Imbaro, Italy

  • Hematology, Ospedale Binaghi, Cagliari, Italy

  • Unit of Lymphoid Malignancies, Department of Hemato-Oncology, San Raffaele Scientific Institute, Milan, Italy

  • Hematology, Ospedale S. Bortolo, Vicenza, Italy

  • Anestesiology, Azienda Ospedaliero-UniversitariaOspedali Riuniti, Foggia, Italy

  • Hematology, Ospedale San Camillo Forlanini, Roma, Italy

  • Department of Medicine, Section of Hematology, University of Verona, Verona, Italy

  • Medical Oncology, Istituto Nazionale dei Tumori, Milano, Italy

Locations

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • B cell lymphomas

  • Diffuse large B-cell lymphoma

Biomarkers

  • Circulating tumor cells

  • Lactate dehydrogenase

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • Mitoxantrone

  • Doxorubicin

  • Etoposide

  • Etoposide phosphate

  • Melphalan

  • Cisplatin

  • Rituximab

  • ara-c

Outcome

  • N/A

Study Design

  • randomized

  • pharmacodynamics

Phase

  • NA

Study Id's

  • NCT00355199

Sponsors

  • N/A

Result

  • Interim

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