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779 : L-Asparaginase Strongly Affects Bioenergetics in Leukemic Cells

Researchers

Presenter

  • Karel Valis

Principal Investigators

  • Karel Fiser

  • Hana Nuskova

  • Jan Trka

  • Julia Starkova

Medical Centers

  • Department of Pediatric Hematology/Oncology, nd Faculty of Medicine, Charles University Prague, Childhood Leukaemia Investigation Prague, Prague, Czech Republic,

  • Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

  • Department of Bioenergetics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

Locations

  • Czech Republic

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Tuberculosis

  • Solid malignancies

Biomarkers

  • Breakpoint Cluster Region

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Platelet Derived Growth Factor Receptor Beta

  • Granulin precursor

  • Serine/threonine-protein kinase mTOR

Drug/Treatment

  • Asparaginase

  • Glutamine

  • Rapacan

  • PX866

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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