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519 : Cooperation Between Aid and the Rag1/Rag2 V(D)J Recombinase Drives Clonal Evolution of Childhood Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Lars Klemm

Principal Investigators

  • Anthony M. Ford

  • Klaus Schwarz

  • Rafael Casellas

  • Lothar Hennighausen

  • Huimin Geng

  • David G. Schatz

  • Michael R. Lieber

  • Mel Greaves

  • Markus Muschen

Medical Centers

  • Haemato-Oncology Research Unit, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, United Kingdom

  • Genome Integrity Group, NIAMS, Bethesda, MD, USA,

  • Institute for Transfusion Medicine, University of Ulm, and Institute for Clinical Transfusion Medicine and Immunogenetics GmbH, Ulm, Germany

Locations

  • United States

  • Germany

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Interleukin-7

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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