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496 : Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation

Researchers

Presenter

  • Maureen A. Shaw

Principal Investigators

  • Kathryn E. McElhinney

  • Keith W. Kombrinck

  • Matthew J. Flick

  • Alexander Brill

  • Denisa D. Wagner

  • Jay L. Degen

Medical Centers

  • Cancer and Blood Diseases Institute, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Venous thrombosis

  • Solid malignancies

Biomarkers

  • Adenomatous Polyposis Coli

  • Prothrombin

Drug/Treatment

  • Thrombomodulin alfa

  • Fibrinogen (IV)

  • Hemostatic Solution

  • Protein C

  • Evithrom

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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