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4869 : Activation of Oxidative Stress and Down-Regulation of Nuclear Factor Erythroid 2-Related Factor May Be Responsible for Disulfiram/Copper Complex Induced Apoptosis in Lymphoid Malignancy Cell Lines

Researchers

Presenter

  • Jie Zha

Principal Investigators

  • Yanyan Zhang

  • Pengcheng Shi

  • Xutao Guo

  • Shiyun Wang

  • Weiguang Wang

  • Bing Xu

Medical Centers

  • Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China

  • Research Institute in Healthcare Science,School of Applied Sciences,Universityof Wolverhampton, Wolverhampton, United Kingdom

Locations

  • China

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Burkitt lymphoma

  • Lymphomas

  • Solid malignancies

Biomarkers

  • c-Jun N-terminal kinase

  • Proto-oncogene tyrosine-protein kinase ROS

  • RELA

Drug/Treatment

  • disulfiram + copper

  • Doxorubicin

  • Disulfiram

  • Alconil

  • Cysteine Hydrochloride

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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