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3559 : Curcumin Potentiates Antitumor Activity of Imatinib Via Inhibition of the AKT/mTOR Signaling Pathway and Down-Regulation of Bcr-Abl Gene in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Yong Guo

Principal Investigators

  • Ting Niu

Medical Centers

  • State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

Locations

  • China

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Philadelphia chromosome–positive (Ph+) ALL

Biomarkers

  • Abelson murine leukemia viral oncogene homolog

  • BCL2 associated X, apoptosis regulator

  • Breakpoint Cluster Region

  • Extracellular signal-regulated kinase

  • Serine/threonine-protein kinase mTOR

  • Signal transducer and activator of transcription 5

Drug/Treatment

  • liposomal curcumin

  • Imatinib

  • IkT001

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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