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3565 : Birinapant (TL32711), a Small Molecule Smac Mimetic, Induces Regressions in Childhood Acute Lymphoblastic Leukemia (ALL) Xenografts That Express TNF? and Synergizes with TNF? in Vitro A Report From the Pediatric Preclinical Testing Program (PPTP)

Researchers

Presenter

  • Malcolm A. Smith

Principal Investigators

  • Hernan Carol

  • Kathryn Evans

  • Jennifer Richmond

  • Min Kang

  • Patrick Reynolds

  • Srinivas Chunduru

  • Martin A. Graham

  • Brian Geier

  • Raushan Kurmasheva

  • Peter J. Houghton

  • Richard B. Lock

Medical Centers

  • Children's Cancer Institute Australia for Medical Research, University of New South Wales, Randwick, Australia

  • Texas Tech University Health Sciences Center, Texas, TX

  • Nationwide Children's Hospital, Columbus, OH

  • Texas Tech University Health Sciences, Lubbock, TX

Locations

  • United States

  • Australia

Companies

  • TetraLogic Pharmaceu

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Rhabdomyosarcoma

  • Rhabdoid predisposition syndrome

  • Ewing's sarcoma

  • Neuroblastoma

  • Solid malignancies

  • Lymphomas

  • Sarcoma

Biomarkers

  • TNF superfamily member 10

  • Tumor necrosis factor

Drug/Treatment

  • birinapant

  • TL32711

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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