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1399 : The Interlaboratory Robustness of Next-Generation Sequencing (IRON) Study Phase II: Deep-Sequencing Analyses of Hematological Malignancies Performed by an International Network Involving 26 Laboratories

Researchers

Presenter

  • Giovanni Martinelli

Principal Investigators

  • Katerina Machova Polakova

  • Marie-Christine Bene

  • Monika Brueggemann

  • Giovanni Cazzaniga

  • Allen Yeoh

  • Soren Lehmann

  • Thomas Ernst

  • Elisabeth Oppliger Leibundgut

  • Ugur Ozbek

  • Ken I Mills

  • Geertruy Kronnie

  • Martin Dugas

  • Christian Thiede

  • Orietta Spinelli

  • Letizia Foroni

  • Joop H. Jansen

  • Andreas Hochhaus

  • Torsten Haferlach

  • Sabina Chiaretti

  • Claude Preudhomme

  • Enrico Tagliafico

  • Jesus Hernandez

  • Christian Gabriel

  • Thomas Lion

  • Peter Vandenberghe

Medical Centers

  • Department of Pediatrics, University of Padova, SSD Ematologia Clinica Sperimentale, Padova, Italy

  • Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany

  • Laboratory Medicine-Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands

  • Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy

  • Department of Oncology, Karolinska University Hospital, Stockholm, Sweden

  • Bern University Hospital and University of Bern, Bern, Switzerland

  • Department of Obstetrics and Gynecology, Universitatsklinikum Halle, Halle, Germany

  • Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy

  • Division of Hematology, Ospedali Riuniti, Bergamo, Italy

  • Molecular genetics, Institute of hematology and blood transfusion, Prague, Czech Republic

  • Professor Doctor, Institute of Experimental Medicine DETAE, Genetics Department, Istanbul University, Istanbul, Turkey

  • Department of Hematology and Oncology, University Hospital, Rostock, Germany

  • Medical Department II, University Medical Center of Schleswig-Holstein Kiel, Kiel, Germany

  • Campus Gasthuisberg, UZ Leuven, Leuven, Belgium

  • Department of Histopathology, Imperial College London, London, United Kingdom

  • Die Blutzentrale Linz, Oesterreichisches Rotes Kreuz, Linz, Austria

  • CHU Nancy, Universite Nancy, Nancy, France

  • Professor, Children's Cancer Research Institute, Wien, Austria

  • CHRU Lille, Universite Lille, Lille, France

  • Institute of Hematology and Medical Oncology, University of Bologna, Bologna, Italy

  • Department of Medicine, National University Hospital, Singapore, Singapore

  • Medical Informatics and Biomathematics, University Hospital of Muenster, Muenster, Germany

  • Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom

  • Munich Leukemia Laboratory, Munich, Germany.

  • Klinik fur Innere Medizin II, Universitatsklinikum Jena, Jena, Germany

Locations

  • Czech Republic

  • Italy

  • Austria

  • Netherlands

  • Singapore

  • Germany

  • Turkey

  • Switzerland

  • United Kingdom

  • France

  • Belgium

  • Sweden

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Chronic Myelogenous Leukemia

  • Myeloid neoplasms

  • Hematological malignancies

  • Myelodysplastic Syndrome

  • Acute myelocytic leukemia

  • Chronic myelomonocytic leukemia

Biomarkers

  • AKT Serine

  • MPL proto-oncogene, thrombopoietin receptor

  • Neurogenic locus notch homolog protein 1

  • Baculoviral IAP repeat-containing protein3

  • Breakpoint Cluster Region

  • Paired box 5

  • Phosphatase and tensin homolog

  • CCAAT enhancer binding protein alpha

  • DNA methyltransferase 3 alpha

  • E3 ubiquitin-protein ligase CBL

  • Enhancer of zeste homolog 2

  • ETV6-RUNX1

  • Exportin 1

  • Histone-lysine N-methyltransferase 2A

  • Isocitrate dehydrogenase 1

  • Isocitrate dehydrogenase 2

  • Tet methylcytosine dioxygenase 2

  • Tumor protein p53

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

  • WT1 Transcription Factor

  • Splicing Factor 3b Subunit 1

Drug/Treatment

  • L-Tyrosine

  • TP53

  • EZH2

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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