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1377 : Exome Sequencing Identifies Recurring DNMT3A Mutations in Adult ETP-ALL

Researchers

Presenter

  • Sandra Heesch

Principal Investigators

  • Cornelia Schlee

  • Thorsten Raff

  • Monika Brueggemann

  • Wolf-Karsten Hofmann

  • Stefan K Bohlander

  • Philipp A Greif

  • Claudia D Baldus

  • Stefan Schwartz

  • Nicola Goekbuget

  • Dieter Hoelzer

  • Nikola P Konstandin

  • Bianka Ksienzyk

  • Alexander Graf

  • Stefan Krebs

  • Helmut Blum

Medical Centers

  • Hematology and Oncology, Charite Campus Benjamin Franklin, Berlin, Germany

  • Laboratory for Functional Genome Analysis at the Gene Center, Ludwig-Maximilians-Universitat (LMU), Munich, Germany

  • Department of Neurosurgery, Ludwig-Maximilians University Munich, Munich, Germany

  • Department of Internal Medicine II, Hematology and Oncology, Goethe University Hospital, Frankfurt, Germany

  • Medical Department II, University Medical Center of Schleswig-Holstein Kiel, Kiel, Germany

  • Dept. of Human Genetics, University of Marburg, Marburg, Germany

  • Department of Hematology and Oncology, University Hospital, Rostock, Germany

  • Department of Hematology and Oncology, Charite, University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany

Locations

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Acute myelocytic leukemia

  • Ovarian cancer

  • Solid malignancies

  • T-cell acute lymphoblastic leukemia

Biomarkers

  • Neurogenic locus notch homolog protein 1

  • Cluster of Differentiation 1a

  • Polycomb complex protein

  • Cluster of differentiation 8A

  • DNA methyltransferase 3 alpha

  • Enhancer of zeste homolog 2

  • ETV6-RUNX1

  • Fms related tyrosine kinase 3

Drug/Treatment

  • EZH2

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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