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1396 : Ultradeep-Amplicon Pyrosequencing for Mutation Detection in the Kinase Domain of BCR-ABL Revealed Artificial Low-Level Variants That Need to Be Avoided for Relevant Mutational Data Interpretation

Researchers

Presenter

  • Simona Soverini

Principal Investigators

  • Caterina De Benedittis

  • Hana Klamova

  • Cyril Salek

  • Marek Trneny

  • Michele Baccarani

  • Giovanni Martinelli

  • Katerina Machova Polakova

Medical Centers

  • Department of Hematology/Oncology, University of Bologna, Bologna, Italy

  • Institute of Hematology and Blood Transfusion, Prague, Czech Republic

Locations

  • Czech Republic

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Chronic Myelogenous Leukemia

  • Philadelphia chromosome–positive (Ph+) ALL

Biomarkers

  • Abelson murine leukemia viral oncogene homolog

  • Breakpoint Cluster Region

  • Immunoglobulin heavy-chain variable region gene

Drug/Treatment

  • Imatinib

  • IkT001

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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