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3501 : Stress Hematopoiesis Reveals Abnormal Control of Self-Renewal, Lineage-Bias and Myeloid Differentiation in Mll Partial Tandem Duplication (Mll-PTD) Hematopoietic Stem/Progenitor Cells

Researchers

Presenter

  • Xiaomei Yan

Principal Investigators

  • Goro Sashida

  • David Witte

  • Qianfei Wang

  • Daniel G Tenen

  • Zhijian Xiao

  • Guido Marcucci

  • James C. Mulloy

  • H. Leighton Grimes

  • Xinghui Zhao

  • Michael A. Caligiuri

  • Gang Huang

  • Yalan Rao

  • Susumu Goyama

  • Susan Whitman

  • Nicholas Zorko

  • Kelsie M. Bernot

  • Rajeana M. Conway

Medical Centers

  • , Tianjin, China

  • Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China

Locations

  • China

Companies

  • N/A

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

  • Genetic Disorder

Disease

  • Acute lymphoblastic leukemia

  • Acute myelocytic leukemia

  • Alpha-thalassemia myelodysplasia syndrome

  • Spinocerebellar ataxia 1

Biomarkers

  • Breakpoint Cluster Region

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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