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3529 : Polo-Like Kinase 1 (PLK1) Inhibition Reduces Cell Proliferation and Induces Apoptosis in Childhood Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Carla Exalto

Principal Investigators

  • Steven C. Clifford

  • Huib N. Caron

  • Rob Pieters

  • Monique L. den Boer

Medical Centers

  • Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands

  • Northern Institute for Cancer Research Newcastle University, Newcastle, United Kingdom

  • Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands

Locations

  • United Kingdom

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Mismatch repair deficiency

  • Solid malignancies

  • B-cell acute lymphoblastic leukemia

  • T-cell acute lymphoblastic leukemia

Biomarkers

  • Polo-like kinase 1

Drug/Treatment

  • Onvansertib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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