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3813 : Hematopoietic Cell Kinase (HCK) Is Highly Expressed in Myelodysplastic Syndrome (MDS) and Regulates Proliferation, Cell Cycle Progression and Hematopoietic Differentiation

Researchers

Presenter

  • Joao Machado-Neto

Principal Investigators

  • Bruna Palodetto

  • Flavia Adolfo Corrocher

  • Mariana Ozello Baratti

  • Paula de Melo Campos

  • Fabiola Traina

  • Sara T Olalla Saad

Medical Centers

  • Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp, Instituto Nacional de Cincia e Tecnologia do Sangue, Brazil, Campinas, Brazil

  • Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil

  • Heesun Hematology and Hemotherapy Center, National Institute of Blood, School of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil

Locations

  • Brazil

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Alpha-thalassemia myelodysplasia syndrome

  • Acute lymphoblastic leukemia

  • Solid malignancies

Biomarkers

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Cluster of Differentiation 34

  • C-X-C motif chemokine receptor 4

  • Serine/threonine-protein kinase mTOR

  • TIMP Metallopeptidase Inhibitor 1

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

Drug/Treatment

  • Rapacan

  • Tretinoin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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