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2609 : Autologous-Collected Donor-Derived CD19-Directed Chimeric Antigen Receptor (CD19-CAR) T Cells Induce a Complete Remission in Chemotherapy-Refractory Childhood Acute Lymphocytic Leukemia (ALL) Relapsing After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT).

Researchers

Presenter

  • Maryalice Stetler-Stevenson

Principal Investigators

  • Marianna Sabatino

  • Barbara Tumaini

  • Kelly Richards

  • Cindy Delbrook

  • James N Kochenderfer

  • Steven A. Rosenberg

  • David Stroncek

  • Crystal L Mackall

  • Alan S Wayne

Medical Centers

  • Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic Lymphocytic Leukemia

  • Acute lymphoblastic leukemia

  • Cytokine release syndrome

  • Hematological malignancies

  • B cell lymphomas

  • Lymphomas

Biomarkers

  • Breakpoint Cluster Region

  • C reactive protein

  • Cytokine

  • Granulocyte-macrophage-colony stimulating factor

  • Interleukin-2

  • Twist-related protein 1

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • fludarabine tablet

  • GM-CSF

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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