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2458 : A Germline Mutation in Cathepsin B in a Child with ALL Points towards a Key Role for This Enzyme in L-Asparaginase Pharmacokinetics.

Researchers

Presenter

  • Esme Waanders

Principal Investigators

  • Marloes Levers

  • Hanka Venselaar

  • Debbie Roeleveld

  • Joachim Boos

  • Claudia Lanvers-Kaminsky

  • Roland P. Kuiper

  • Peter M. Hoogerbrugge

  • Frank N. van Leeuwen

  • D. Maroeska W.M. te Loo

Medical Centers

  • Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany

  • Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands

  • Centre for Molecular and Biomolecular Informatics, Radboud University Medical Centre Nijmegen, Nijmegen, Netherlands

  • Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands

  • Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands

Locations

  • Germany

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Breakpoint Cluster Region

Drug/Treatment

  • Asparaginase

  • Erwinase

Outcome

  • N/A

Study Design

  • pharmacokinetics

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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