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2384 : Abrogation of MLL-AF10 and CALM-AF10 Mediated Transformation Through Genetic Inactivation or Pharmacological Inhibition of the H3K79 Methyltransferase DOT1L.

Researchers

Presenter

  • Aniruddha J Deshpande

Principal Investigators

  • Deepti Banka

  • Bernt Kathrin

  • Stuart Dias

  • Christian Buske

  • Edward J Olhava

  • Scott R Daigle

  • Victoria M Richon

  • Roy M Pollock

  • Scott A. Armstrong

Medical Centers

  • Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA,

  • University Hospital of Ulm, Institute of Experimental Cancer Research, Ulm, Germany

Locations

  • United States

  • Germany

Companies

  • Epizyme, Inc.

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Acute myelocytic leukemia

Biomarkers

  • Breakpoint Cluster Region

Drug/Treatment

  • EPZ004777

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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