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2563 : Suppressor of Cytokine Signaling (SOCS) Molecules Are Critical to Balance Oncogenic Signaling Strength in Ph+ ALL.

Researchers

Presenter

  • Huimin Geng

Principal Investigators

  • Lars Klemm

  • Maike Buchner

  • Kaveh Hemati

  • Seyedmehdi Shojaee

  • Warren S. Alexander

  • William L. Carroll

  • Cheryl L Willman

  • Markus Muschen

Medical Centers

  • Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

  • Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA

Locations

  • United States

  • Australia

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Philadelphia chromosome–positive (Ph+) ALL

Biomarkers

  • Breakpoint Cluster Region

  • p53

  • Phosphorylated signal transducer and activator of transcription 5

  • Proto-oncogene tyrosine-protein kinase ROS

  • Cytokine

  • Janus kinase

  • Suppressor Of Cytokine Signaling 3

Drug/Treatment

  • L-Tyrosine

  • Afimoxifene

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Interim

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